Robert L. Unckless

Evolutionary and ecological genomics


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#365 Papers – February update

I found myself behind this month, but was able to catch up due to some home days.  Arvid and Emily are machines.  A few of my favorites this month were Hamilton et al. 2016, Yamaguchi et al. 2015, Pipoly et al. 2015 and Mcdonald et al. 2016.

Here’s my entire list…

Yu et al 2016 AAC -The More The Better? Combination Effects of Antimicrobial Peptides – http://aac.asm.org/content/early/2016/01/04/AAC.02434-15.full.pdf+html
Kern et al 2015 Biology Letters -Double trouble: combined action of meiotic drive and Wolbachia feminization in Eurema butterflies. – http://www.ncbi.nlm.nih.gov/pubmed/25948567
Yamamoto-Hino and Soto 2016 Cell Structure and Function -Spätzle-processing enzyme-independent activation of the Toll pathway in Drosophila innate immunity. – http://www.ncbi.nlm.nih.gov/pubmed/26843333
Bronkhorst et al 2012 PNAS – The DNA virus Invertebrate iridescent virus 6 is a target of the Drosophila RNAi machinery – http://www.pnas.org/cgi/pmidlookup?view=long&pmid=23151511
Carvalho et al 2015 PNAS – Birth of a new gene on the Y chromosome of Drosophila melanogaster. – http://www.pnas.org/content/112/40/12450.long
Zhao et al 2015 Dev. Bio. – The IMD innate immunity pathway of Drosophila influences somatic sex determination via regulation of the Doa locus. – http://www.sciencedirect.com/science/article/pii/S0012160615302074
Manuscript review
Lynch et al 2016 JEB – Evolution of behavioral and cellular defenses against parasitoid wasps in the Drosophila melanogaster subgroup – http://onlinelibrary.wiley.com/doi/10.1111/jeb.12842/abstract
Kariithi et al 2013 – JGV – Correlation between structure, protein composition, morphogenesis and cytopathology of Glossina pallidipes salivary gland hypertrophy virus – http://www.ncbi.nlm.nih.gov/pubmed/23052395
Strand and Burke 2015 ARV – Polydnaviruses: Nature’s Genetic Engineers – http://www.annualreviews.org/doi/abs/10.1146/annurev-virology-031413-085451
Bezier et al 2015 Journal of Virology- The Genome of the Nucleopolyhedrosis-Causing Virus from Tipula oleracea Sheds New Light on the Nudiviridae Family – http://jvi.asm.org/content/89/6/3008.full
Grant Draft
Wang et al 2008 Journal of Virological Methods – Sequencing of the large dsDNA genome of Oryctes rhinoceros nudivirus using multiple displacement amplification of nanogram amounts of virus DNA – http://www.sciencedirect.com/science/article/pii/S0166093408002073
Grimaldi et al 2015 PLoS ONE -Strange Little Flies in the Big City: Exotic Flower-Breeding Drosophilidae (Diptera) in Urban Los Angeles – http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122575
Mistry et al 2016 DCI – Exploring interactions between pathogens and the Drosophila gut.- http://www.ncbi.nlm.nih.gov/pubmed/26876781
Brandvain and Wright. 2016. Trends Genetics. The limits of natural selection in a nonequilibrium world http://www.cell.com/trends/genetics/fulltext/S0168-9525(16)00014-7
Zanders and Malik 2015 Current Biology – Chromosome Segregation: Human Female Meiosis Breaks All the Rules- http://www.cell.com/current-biology/abstract/S0960-9822(15)00781-2
Halldorsdottir and Arnason 2015 PeerJ -Trans-species polymorphism at antimicrobial innate immunity cathelicidin genes of Atlantic cod and related species – https://peerj.com/articles/976.pdf
Hamilton et al 2015 mBio – Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association- http://mbio.asm.org/content/6/5/e01356-15.full.pdf+html
Manuscript review
Yamauchi et al 2016 Science -Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction. -http://www.ncbi.nlm.nih.gov/pubmed/26823431
Miller et al 2016 PNAS – Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster- http://www.pnas.org/content/early/2016/02/17/1601232113.abstract
Zeng et al 2016 BMC Evolutionary Biology – Balancing selection and recombination as evolutionary forces caused population genetic variations in golden pheasant MHC class I genes- http://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-016-0609-0
Pipoly et al 2015 Nature – The genetic sex-determination system predicts adult sex ratios in tetrapods -http://www.nature.com/nature/journal/v527/n7576/full/nature15380.html
Steinhauer 2015 Spermatogenesis – Separating from the pack: Molecular mechanisms of Drosophila spermatid individualization – http://www.tandfonline.com/doi/pdf/10.1080/21565562.2015.1041345
Zhong et al. 2016 Scientific Reports -Co-expression of Dorsal and Rel2Negatively Regulates Antimicrobial Peptide Expression in the Tobacco Hornworm Manduca sexta – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742911/pdf/srep20654.pdf
Besnard-Guerin et al 2015 PLOS One -The Cricket Paralysis Virus Suppressor Inhibits microRNA Silencing Mediated by the Drosophila Argonaute-2 Protein – http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120205
Metzger et al 2016 Evolution – The Red Queen lives: Epistasis between linked resistance loci – http://onlinelibrary.wiley.com/doi/10.1111/evo.12854/abstract
McDonald et al. 2016. Nature. Sex speeds adaptation by altering the dynamics of molecular evolution http://www.nature.com/nature/journal/vaop/ncurrent/full/nature17143.html

This is Arvid Agren’s list:

Molaro and Malik. 2016. Curr. Opin. Genet. Dev Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germline http://www.sciencedirect.com/science/article/pii/S0959437X15001422
Stuart et al. 2014. Science. Rapid evolution of a native species following invasion by a congener classic.sciencemag.org/content/346/6208/463.long#ref-1
Arkhipova and Rice 2016 Mol Ecol Mobile Genetic Elements: In Silico, In Vitro, In Vivo onlinelibrary.wiley.com/doi/10.1111/mec.13543/abstract
Theis et al. 2016. BioRxiv Getting the Hologenome Concept Right: An Eco-Evolutionary Framework for Hosts and Their Microbiomes biorxiv.org/content/early/2016/02/02/038596
Journal of Evolutionary Biology – Review
Okasha. 2004. Biol Philos. The “averaging fallacy” and the levels of selection link.springer.com/article/10.1023/B:BIPH.0000024406.61340.6c
Galbraith et al. 2016. PNAS Testing the kinship theory of intragenomic conflict in honey bees (Apis mellifera) http://www.pnas.org/content/113/4/1020.abstract
Poirotte et al. 2016. Current Biology. Morbid attraction to leopard urine in Toxoplasma-infected chimpanzees http://www.sciencedirect.com/science/article/pii/S0960982215015171
Lescak et al. 2015. PNAS. Evolution of stickleback in 50 years on earthquake-uplifted islands http://www.pnas.org/content/112/52/E7204.full
Carvalho et al. 2015. PNAS. Birth of a new gene on the Y chromosome of Drosophila melanogaster http://www.pnas.org/content/112/40/12450.long
Brandvain and Wright. 2016. Trends Genetics. The limits of natural selection in a nonequilibrium world http://www.cell.com/trends/genetics/fulltext/S0168-9525(16)00014-7
Immonen et al. 2016. JEB. Complex mitonuclear interactions and metabolic costs of mating in male seed beetles onlinelibrary.wiley.com/doi/10.1111/jeb.12789/full
Arnqvist et al. 2010. Evolution. Genetic architecture of metabolic rate: environment specific epistasis between mitochondrial and nuclear genes in an insect http://onlinelibrary.wiley.com/doi/10.1111/j.1558-5646.2010.01135.x/
Immonen et al. 2016. Heredity. Direct and indirect genetic effects of sex-specific mitonuclear epistasis on reproductive ageing http://www.nature.com/hdy/journal/v116/n3/full/hdy2015112a.html
Dobler et al. 2014. JEB. A meta-analysis of the strength and nature of cytoplasmic genetic effects onlinelibrary.wiley.com/doi/10.1111/jeb.12468/full
Traverse et al. 2012. PNAS. Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections http://www.pnas.org/content/110/3/E250.long
Cotner et al. 2014. Reports of the National Center for Science Education. Science and society. Evolution and student voting patterns http://reports.ncse.com/index.php/rncse/article/view/142
Maumus and Quesneville. 2016. Curr Opin Plant Biol Impact and insights from ancient repetitive elements in plant genomes http://www.sciencedirect.com/science/article/pii/S1369526616300036
Buzzoni. 2015. J Gen Philos Sci Causality, teleology, and thought experiments in biology link.springer.com/article/10.1007/s10838-015-9293-9/fulltext.html
Korb and Heinze. 2016. Ann Rev Entomol. Major hurdles in the evolution of sociality http://www.annualreviews.org/doi/abs/10.1146/annurev-ento-010715-023711
Beerenwinkel et al. 2016. PLoS Comput Biol. Computational cancer biology: An evolutionary perspective journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004717#sec001
Wit et al. 2013. Exp Geront. Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span http://www.sciencedirect.com/science/article/pii/S0531556513000235
Soria-Carrasco et al. 2014. Science. Stick insect genomes reveal natural selection’s role in parallel speciation science.sciencemag.org/content/344/6185/738.full
Yanai and DeLisli. 2002. Genome Biol. The society of genes: networks of functional links between genes from comparative genomics http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133448/
Lindholm et al. 2016. TREE. The ecology and evolutionary dynamics of meiotic drive http://www.cell.com/trends/ecology-evolution/fulltext/S0169-5347(16)00043-4
McDonald et al. 2016. Nature. Sex speeds adaptation by altering the dynamics of molecular evolution http://www.nature.com/nature/journal/vaop/ncurrent/full/nature17143.html
Rainey and De Monte. 2014. Annu. Rev. Ecol. Evol. Syst. Resolving conflicts during the evolutionary transition to multicellular life http://www.annualreviews.org/doi/full/10.1146/annurev-ecolsys-120213-091740
Kirkpatrick and Guerrero. 2014. Genetics. Signatures of sex-antagonistic selection on recombining sex chromosomes http://www.genetics.org/content/197/2/531.full#fn-group-1
van Doorn and Kirkpatrick. 2007. Nature. Turnover of sex chromosomes induced by sexual conflict http://www.nature.com/nature/journal/v449/n7164/full/nature06178.html#B13

Here’s Emily Davenport’s list:

Theis et al. BioRxiv 2016; Getting the hologenome concept right: An eco-evolutionary framework for hosts and their microbiomes
Hu et al. Nature Communications 2016; GWAS of 89,283 individuals identifies genetic variants associated with self-reporting ob being a morning person
Morton et al. PLoS Genetics 2015; Variation in rural African gut microbiota is strongly correlated with colonization by Entamoeba and subsistence
Dominguez-Bello et al. Nature Medicine 2016; Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
Milani et al. Applied and Environmental Microbiology 2016; Genomics of the genus Bifidobacterium reveals species-specific adaptation to the glycan-rich gut environment
Gamazon et al. Nature Genetics 2015; A gene-based association method for mapping traits using reference transcriptome data
Loose et al. BioRxiv 2016; Real time selective sequencing using nanopore technology
Terrell et al. PeerJ Preprints 2016; Gender bias in open source: Pull request acceptance of women versus men
Minica et al. Molecular Psychiatry 2014; MZ twin pairs of MZ singletons in population family-based GWAS? More power in pairs
Thornton et al. PLoS Genetics 2013; Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in gene of large effect
Sanjak et al. G3 2016; Efficient software for multi-marker, region-based analysis of GWAS data
Simonti et al. Science 2016; The phenotypic legacy of admixture between modern humans and Neandertals
Gibson et al. PLoS Computational Biology 2016; On the origins and control of community types in the human microbiome
Clooney et al. PLoS One 2016; Comparing apples and oranges?: Next generation sequencing and its impact on microbiome analysis
Gage et al. PLoS Genetics 2016; G = E: What GWAS can tell us about the environment
Denny et al. Nature Biotechnology 2013; Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
Manuscript review
Lanan et al. ISME 2016; A bacterial filter protects and structures the gut microbiome of an insect
Blanton et al. Science 2016; Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children
McGeachie et al. Scientific Reports 2016; Longitudinal prediction of the infant gut microbiome with dynamic bayesian networks
Schweizer Burguete et al. eLife 2015; GGGGCC micrsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function
Sveinbjornsson et al. Nature Genetics 2016; Weighting sequence variants based on their annotation increases power of whole-genome association studies
Paliy et al. Molecular Ecology 2016; Application of multivariate statistical techniques in microbial ecology
Ma et al. Nature Communications 2016; Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts
Fonseca-Garcia et al. Frontiers in Microbiology 2016; The cacti microbiome: Interplay between habitat-filtering and host-specificity
Gomez et al. Cell Reports 2016; Gut microbiome of coexisting BaAka pygmies and Bantu reflects gradients of traditional subsistence patterns
Weiss et al. ISME 2016; Correlation detection strategies in microbial data sets vary widely in sensitivity and precision
Noecker et al. mSystems 2016; Metabolic model-based integration of microbiome taxonomic and metabolomic profiles elucidates mechanistic links between ecological and metabolic variation
Charbonneau et al. Cell 2016; Sialylated milk oligosaccharides promote microbiota-dependent growth in models of infant undernutrition


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New Meiotic Drive Review in TREE

Last summer I was lucky enough to participate in a meiotic drive meeting in Arolla, Switzerland.  The organizers, Tom Price and Anna Lindholm, told us that we would spend the first two days presenting our recent findings, the next day brainstorming and outlining an invited review for Trends in Ecology and Evolution and the final two days writing a first draft.  I think the general consensus was that they were crazy and that such a plan was way too ambitious.  Amazingly, their plan is exactly how it happened.  The group was wonderful to work with and we finished the meeting with a rough but full draft. The paper was published online today and can be found here.  In case you are feeling bad for us for having to work so hard for those five days, check out the view from our hike.

IMG_4188


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#365Papers – month #1

There’s a Clark lab effort to improve the amount that we read by participating in the #365Papers challenge.  I didn’t really want to tweet each one out as I go, but publishing a monthly update here helps keeps me honest.  So this is the list for January 2016…

Hamilton et al 2015 PNAS – http://www.pnas.org/content/early/2015/12/23/1518648113.abstract
Helenius et al. 2015 J Immunol – http://www.jimmunol.org/content/early/2015/12/06/jimmunol.1501708.abstract
Kutch and Fedorka 2015 Proc Biol Sci – http://rspb.royalsocietypublishing.org/content/royprsb/282/1820/20151301.full.pdf
Evolution – Review
Palopoli et al 2015 PNAS – http://www.pnas.org/content/112/52/15958.full.pdf
Vanha-aho et al 2016 Immun. Letters – http://www.sciencedirect.com/science/article/pii/S0165247815300791
Leshchinsky and Klasing 2001 DCI – http://www.sciencedirect.com.proxy.library.cornell.edu/science/article/pii/S0145305X01000234?np=y
Nguyen et al 1998 Aust Vet J – http://onlinelibrary.wiley.com/doi/10.1111/j.1751-0813.1998.tb10241.x/pdf
Chae et al 2014 Cell – http://www.sciencedirect.com/science/article/pii/S0092867414013762
Lambiable et al 2016 PNAS – http://www.pnas.org/content/early/2016/01/05/1516122113.abstract
Chakraborty et al 2015 BioRxiv – http://biorxiv.org/content/early/2015/10/16/029306
Chakraborty and Fry 2016 Current Biology – http://www.ncbi.nlm.nih.gov/pubmed/26748852
Zug and Hammerstein 2015 Frontiers in Microbiology – http://journal.frontiersin.org/article/10.3389/fmicb.2015.01201/abstract
Avadhanula et al 2009 PLoS Pathogens – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738967/pdf/ppat.1000582.pdf
Boettiger et al 2016 Nature – http://www.ncbi.nlm.nih.gov/pubmed/26760202
Costa et al 2009 PLOS ONE – http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0007436&representation=PDF
Grant proposal
Dideon et al 2015 BioRxiv – http://biorxiv.org/content/early/2015/10/14/024851
Malone et al 2015 Curr Op Gen Dev http://www.sciencedirect.com/science/article/pii/S0959437X15000969
Allen et al 2015 Current Biology – http://www.cell.com/current-biology/abstract/S0960-9822(15)01490-6
Lack et al 2016 PNAS – http://www.pnas.org.proxy.library.cornell.edu/content/early/2016/01/08/1515964113.long
Yassin et al 2016 Nature Communication – http://www.nature.com/ncomms/2016/160118/ncomms10400/full/ncomms10400.html
Faria et al 2015 Evolution – Evolution of Drosophila resistance against different pathogens and infection routes entails no detectable maintenance costs – http://www.ncbi.nlm.nih.gov/pubmed/26496003
Cao et al 2016 PLOS Pathogens -A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rhabdovirus in Drosophila – http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005387
Sedghifar et al 2016 Genetics – Genomic patterns of geographic differentiation in Drosophila simulans – http://www.genetics.org/cgi/pmidlookup?view=long&pmid=26801179
Erkosar et al 2015 Cell Host Microbe – Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion – http://www.sciencedirect.com/science/article/pii/S1931312815003704
Wang et al 2015 Databases -FlyVar: a database for genetic variation in Drosophila melanogaster – http://database.oxfordjournals.org/content/2015/bav079.long
Wang et al 2015 Science Advances – Drosophila Dicer-2 has an RNA interference–independent function that modulates Toll immune signaling – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646792/pdf/1500228.pdf
Carrillo et al 2013 Plant Pathology – Lateral transfer of a phytopathogenic symbiont among native and exotic ambrosia beetles – http://onlinelibrary.wiley.com/doi/10.1111/ppa.12073/abstract
Dudzic et al 2015 BMC Biology – Drosophila innate immunity: regional and functional specialization of prophenoloxidases – http://bmcbiol.biomedcentral.com/articles/10.1186/s12915-015-0193-6
Faye et al 2014 PLOS NTD – Molecular Evolution of Zika Virus during Its Emergence in the 20th Century – http://journals.plos.org/plosntds/article/asset?id=10.1371/journal.pntd.0002636.PDF

 

Below is Arvid Agren’s (@arvidagren) list.  He’s read some very interesting looking stuff….

 

Akçay and Van Cleve 2016 Proc B There is no fitness but fitness, and the lineage is its bearer http://rstb.royalsocietypublishing.org/content/371/1687/20150085
Mascagni et al 2015 GBE Repetitive DNA and Plant Domestication: Variation in Copy Number and Proximity to Genes of LTR-Retrotransposons among Wild and Cultivated Sunflower (Helianthus annuus) Genotypes http://gbe.oxfordjournals.org/content/7/12/3368.full
O’Malley and Powell 2016 Biol Philos Major problems in evolutionary transitions: how a metabolic perspective can enrich our understanding of macroevolution http://link.springer.com/article/10.1007%2Fs10539-015-9513-z
Kovaka 2015 Philos. Sci. Biological Individuality and Scientific Practice https://www.jstor.org/stable/10.1086/683443?seq=1#page_scan_tab_contents
Ewing 2015 Mobile DNA Transposable element detection from whole genome sequence data http://www.mobilednajournal.com/content/6/1/24
Rahman et al. 2015. Nucl. Acids. Res Unique transposon landscapes are pervasive across Drosophila melanogaster genomes http://nar.oxfordjournals.org/content/43/22/10655.long
Mallet et al. 2015. BioEssays. How reticulated are species? onlinelibrary.wiley.com/doi/10.1002/bies.201500149/full
Okasha and Martens 2016 JEB Hamilton’s Rule, Inclusive Fitness Maximization, and the Goal of Individual Behaviour in Symmetric Two-Player Games http://onlinelibrary.wiley.com/doi/10.1111/jeb.12808/abstract
Hartfield et al. 2016. Genetics. Coalescent Times and Patterns of Genetic Diversity in Species with Facultative Sex: Effects of Gene Conversion, Population Structure, and Heterogeneity http://www.genetics.org/content/202/1/297.full-text.pdf+html
Brunet and Doolittle. 2015. GBE. Multilevel selection theory and the evolutionary functions of transposable elements https://gbe.oxfordjournals.org/content/7/8/2445.abstract
Sterelny and Kitcher. 1988. J Phil The return of the gene http://www.jstor.org/stable/2026953?seq=1#page_scan_tab_contents
Kapheim et al. 2015. Science. Genomic signatures of evolutionary transitions from solitary to group living http://www.sciencemag.org/content/348/6239/1139.full
Maynard Smith. 1987. How to model evolution. In “The Latest on the Best” (J Dupre ed.) https://newcatalog.library.cornell.edu/catalog/1323528
Manuscript draft
Rollins et al. 2016. MBE Selection on mitochondrial variants occurs between and within individuals in an expanding invasion http://mbe.oxfordjournals.org/content/early/2016/01/05/molbev.msv343.abstract
Lander. 20116. Cell The Heroes of CRISPR http://www.cell.com/cell/fulltext/S0092-8674(15)01705-5
Rosenberg 1993 Midwest Stud Phil Genic slection, molecular biology and biological instrumentalism http://onlinelibrary.wiley.com/doi/10.1111/j.1475-4975.1993.tb00272.x/abstract
Griffin et al. 2015. JEB Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster onlinelibrary.wiley.com/doi/10.1111/jeb.12708/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=
Camus et al. Curr Biol 2012 Mitochondria, maternal inheritance, and male aging cambridge.org/au/academic/subjects/philosophy/philosophy-science/organisms-agency-and-evolution?format=HB
Beekman et al. 2014 Proc B The costs of being male: are there sex-specific effects of uniparental mitochondrial inheritance? rstb.royalsocietypublishing.org/content/369/1646/20130440
Yee et al. 2015 Evolution Intergenomic interactions between mitochondrial and Y‐linked genes shape male mating patterns and fertility in Drosophila melanogaster onlinelibrary.wiley.com/doi/10.1111/evo.12788/full
Dean et al. 2015 JEB Context-dependent effects of Y chromosome and mitochondrial haplotype on male locomotive activity in Drosophila melanogaster onlinelibrary.wiley.com/doi/10.1111/jeb.12702/abstract
Waters. 1990. Biol and Philos Rosenberg’s rebellion link.springer.com/article/10.1007%2FBF00127490#page-1
Felsenstein. 2001. Syst. Biol. The troubled growth of statistical phylogenetics http://evolution.genetics.washington.edu/papers/statphyl/statphyl.pdf
Kofler et al. 2015. PLoS Genetics Tempo and mode of transposable element activity in Drosophila http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005406#references
Haig. 1996. PNAS Gestational drive and the green-bearded placenta http://www.pnas.org/content/93/13/6547.full.pdf
Foster. 2006. JEB. Balancing synthesis with pluralism in sociobiology onlinelibrary.wiley.com/doi/10.1111/j.1420-9101.2006.01188.x/full
Current Zoology – Review
Krupp. 2016. TREE Causality and the levels of selection http://www.cell.com/trends/ecology-evolution/fulltext/S0169-5347(16)00023-9
Herron. 2015. Mol Ecol. Origins of Multicellular Complexity: Volvox and the Volvocine Algae onlinelibrary.wiley.com/doi/10.1111/mec.13551/abstract
Manuscript draft


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New paper on convergent balancing selection in Drosophila

A paper I wrote with Ginny Howick and Brian Lazzaro was published in Current Biology today.  The link is here: Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila It was a lot of fun and started as a questionable GWAS hit for a completely different project.  What we find is that the same amino acid polymorphism in the antimicrobial peptide, Diptericin, segregates in D. melanogaster and D. simulans and that the two alleles have very different effects in terms of immune defense.  Null alleles also segregate in both species at relatively high frequencies and are associated with very poor immune defense.  In D. simulans, a tandem duplication of Diptericin is segregating.


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The Unckless lab at the University of Kansas

438px-university_of_kansas_jayhawk_logo-svgIn August, I will be starting a lab at the University of Kansas in the Department of Molecular Biosciences.  I’m thrilled for this opportunity and will be looking to take graduate students and hire technicians and postdocs.  Please send me a message if you are interested.  Check out my amazing colleagues at http://molecularbiosciences.ku.edu/faculty and http://eeb.ku.edu/faculty.  More to come as we get closer to the date…